The roles of integrin β4 in Vascular Endothelial Cells
Identifieur interne : 001330 ( Main/Exploration ); précédent : 001329; suivant : 001331The roles of integrin β4 in Vascular Endothelial Cells
Auteurs : Li Wang [République populaire de Chine] ; Zhiwu Dong [République populaire de Chine] ; Yun Zhang [République populaire de Chine] ; Junying Miao [République populaire de Chine]Source :
- Journal of Cellular Physiology [ 0021-9541 ] ; 2012-02.
English descriptors
- Teeft :
- Adhesion, Angiogenesis, Apoptosis, Autophagy, Beta4, Biochem, Biochem biophys, Biol, Chem, Cytoplasmic, Deprivation, Dong, Endothelial, Endothelial apoptosis, Endothelial cells, Giancotti, Integrin, Integrin beta4, Integrins, Mercurio, Miao, Pathway, Rattlesnake venom, Senescence, Subunit, Transduction, Vascular, Vecs, Wang, Zhang, Zhao.
Abstract
Integrin heterodimers play diverse and important roles in physiological and pathological processes, such as cell adhesion, migration, proliferation, differentiation, angiogenesis, and tumor progression, via the outside‐in and/or inside‐out signaling pathways. Aberrant functions of integrins have been implicated in the causation and intervention of multiple diseases. Integrin β4, a laminin‐5 (LN5) receptor, mainly locates in the adhesion structure of hemidesmosome (HD). Most of the previous researches concentrated on the role of integrin β4 in cancer and cancer therapy, and a few focused on the physiological roles of normal mammalian cells. Recently, accumulating data reveal that integrin β4 participates in cell death, macroautophagy (hereafter autophagy), senescence, and differentiation regulations in various cell types including human umbilical vein endothelial cells (HUVECs), mesenchymal stem cells, and mouse neural cells, implying the key roles of integrin β4 in the physiological alteration of mammalian cells. Thus, the elucidation of integrin β4‐mediated signaling may undoubtedly contribute to novel therapeutic strategies for various human diseases, such as vascular and neural disorders. We have reviewed the roles of integrin β4 in neural cells. In the present review we will discuss the recent research progress in the inherent functions and pharmacological modulation of integrin β4 in vascular endothelial cells. J. Cell. Physiol. 227: 474–478, 2012. © 2011 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jcp.22769
Affiliations:
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Institute of Developmental Biology, School of Life Science, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Zhiwu" sort="Dong, Zhiwu" uniqKey="Dong Z" first="Zhiwu" last="Dong">Zhiwu Dong</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Science, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yun" sort="Zhang, Yun" uniqKey="Zhang Y" first="Yun" last="Zhang">Yun Zhang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Miao, Junying" sort="Miao, Junying" uniqKey="Miao J" first="Junying" last="Miao">Junying Miao</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Science, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Correspondence address: Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100</wicri:regionArea><wicri:noRegion>Jinan 250100</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cellular Physiology</title><title level="j" type="alt">JOURNAL OF CELLULAR PHYSIOLOGY</title><idno type="ISSN">0021-9541</idno><idno type="eISSN">1097-4652</idno><imprint><biblScope unit="vol">227</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="474">474</biblScope><biblScope unit="page" to="478">478</biblScope><biblScope unit="page-count">5</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-02">2012-02</date></imprint><idno type="ISSN">0021-9541</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9541</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adhesion</term><term>Angiogenesis</term><term>Apoptosis</term><term>Autophagy</term><term>Beta4</term><term>Biochem</term><term>Biochem biophys</term><term>Biol</term><term>Chem</term><term>Cytoplasmic</term><term>Deprivation</term><term>Dong</term><term>Endothelial</term><term>Endothelial apoptosis</term><term>Endothelial cells</term><term>Giancotti</term><term>Integrin</term><term>Integrin beta4</term><term>Integrins</term><term>Mercurio</term><term>Miao</term><term>Pathway</term><term>Rattlesnake venom</term><term>Senescence</term><term>Subunit</term><term>Transduction</term><term>Vascular</term><term>Vecs</term><term>Wang</term><term>Zhang</term><term>Zhao</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Integrin heterodimers play diverse and important roles in physiological and pathological processes, such as cell adhesion, migration, proliferation, differentiation, angiogenesis, and tumor progression, via the outside‐in and/or inside‐out signaling pathways. Aberrant functions of integrins have been implicated in the causation and intervention of multiple diseases. Integrin β4, a laminin‐5 (LN5) receptor, mainly locates in the adhesion structure of hemidesmosome (HD). Most of the previous researches concentrated on the role of integrin β4 in cancer and cancer therapy, and a few focused on the physiological roles of normal mammalian cells. Recently, accumulating data reveal that integrin β4 participates in cell death, macroautophagy (hereafter autophagy), senescence, and differentiation regulations in various cell types including human umbilical vein endothelial cells (HUVECs), mesenchymal stem cells, and mouse neural cells, implying the key roles of integrin β4 in the physiological alteration of mammalian cells. Thus, the elucidation of integrin β4‐mediated signaling may undoubtedly contribute to novel therapeutic strategies for various human diseases, such as vascular and neural disorders. We have reviewed the roles of integrin β4 in neural cells. In the present review we will discuss the recent research progress in the inherent functions and pharmacological modulation of integrin β4 in vascular endothelial cells. J. Cell. Physiol. 227: 474–478, 2012. © 2011 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></noRegion><name sortKey="Dong, Zhiwu" sort="Dong, Zhiwu" uniqKey="Dong Z" first="Zhiwu" last="Dong">Zhiwu Dong</name><name sortKey="Miao, Junying" sort="Miao, Junying" uniqKey="Miao J" first="Junying" last="Miao">Junying Miao</name><name sortKey="Miao, Junying" sort="Miao, Junying" uniqKey="Miao J" first="Junying" last="Miao">Junying Miao</name><name sortKey="Miao, Junying" sort="Miao, Junying" uniqKey="Miao J" first="Junying" last="Miao">Junying Miao</name><name sortKey="Miao, Junying" sort="Miao, Junying" uniqKey="Miao J" first="Junying" last="Miao">Junying Miao</name><name sortKey="Zhang, Yun" sort="Zhang, Yun" uniqKey="Zhang Y" first="Yun" last="Zhang">Yun Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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